Questions List

Posted onOctober 8, 2023 11:24 am

Posted onOctober 8, 2023 11:24 am

Posted onOctober 8, 2023 11:24 am

Posted onOctober 7, 2023 10:05 pm

Thank you for all your work putting on this virtual meeting. I was able to attend some of the sessions from Canada (EST). Always find it so interesting. With regards, Helen Driver.Posted onOctober 6, 2023 5:02 pm

Hello. I have one question out of thema but still very important about night hypoventilation in children. In AASM is >25%. In recent paper ERS - 2% co2 above 50mmHg. Where hides the secret in such a difference? Thank you. Dr.Berke pediatric pneumonologist, LatviaPosted onOctober 6, 2023 4:59 pm

Thank you for sharing your knowledge! What du you think about the use of polygrafi kontra polysomnografi in children? From Olaug in NorwayPosted onOctober 6, 2023 4:57 pm

What are your perspectives on overnight oximetry to screen for sleep apnea? Do you use the McGill Score to triage for tonsillectomy?Posted onOctober 6, 2023 4:55 pm

And what about myofunctional therapy?Posted onOctober 6, 2023 4:51 pm

What are your perspectives on level 3 home studies for children please? Wonderful session. ThanksPosted onOctober 6, 2023 4:51 pm

if any more episodes then= surgery.Posted onOctober 6, 2023 4:45 pm

was sent fromthe neuro-pediatrician i agreed Posted onOctober 6, 2023 4:44 pm

Thank you to the speakers for these great presentations. What do you think about the relationship between bruxism and AOS?. Maybe bruxism could be an AOS phenotipe?Posted onOctober 6, 2023 4:42 pm

Clinical case: 4 year old that i have operated on the adenoids at 2 and a half, now has suspicion of epilepsy in the ormat of absences but not confirmed with eeg or RM, but has an ahi of 2/h. i medicated with montelucaste and nasal corticosteroid. he has tonsils grade 2 of hypertrophy. watchful waiting versus surgery? i suggested watchful waiting and then see if he has any more absences before proposing surgery and see him in one- two months. would you suggest anything different? (joana, portugal). No other symptoms associated with OSA except maybe ocasional mouth breathing and snoring.Posted onOctober 6, 2023 4:37 pm

Q to Dr. van Looij from Dr. Peraita (Spain) - Do you use the radiofrequency tonsil reduction?Posted onOctober 6, 2023 4:29 pm

Oliver Weber. Germany - could be OSA, lack of sleep or poor sleep quality be responsible for developing ADHD/ADD in children? Cognitive problems were mentioned. So is ADHD/ADD involved in this conclusion? Posted onOctober 6, 2023 4:12 pm

Thank you for your presentation Dr. Athanasios & Dr Oscar. Can you put more light on decision making of treatment options. Any more suggestions on other non - pharmacological methods Thank you Posted onOctober 6, 2023 4:05 pm

To Athanasios Katidis: What are the Central apnea index cut-offs for diagnosing CSA in children as central apneas are more frequently encountered normally in children?Posted onOctober 6, 2023 3:54 pm

I have just asked a questionPosted onOctober 6, 2023 3:34 pm

Dr. Akersted: How do you see the results of worse outcome for women related to short sleep considering that women will live a physiological period of short sleep with breastfeeding and if we consider historically this used to be a great part of women´s life.Posted onOctober 6, 2023 3:33 pm

Prof. Akerstedt, great talk. Given your exertise, I have a question related to the work you have presented today. Do you have any explanation for the association between longer sleep durations and higher moratility risk found in some research? Thank you in advance. Ana Gomes (Portuga) Posted onOctober 6, 2023 3:33 pm

to Torbjörn Åkerstedt: How do you find that sleep disorders and cancer mortality? Because there are lots of cancer types and treatment lines. What is your investigation method to compare that large data and can you link cancer mortality with sleep + gender? Caner Sahin-Turkey Posted onOctober 6, 2023 3:28 pm

I'm Ana RIvera from Mexico City. My question is for Dr. Mihyeon Kim. Did you observe any differences between sleep arrangements (cosleep vs sleep training etc) in your results?Posted onOctober 6, 2023 3:28 pm

Thank you for your replies Dr Salvador and Dr Torbjorn for your input.Posted onOctober 6, 2023 3:27 pm

Apologies thatquestion is for Dr Torbjorn. Thank you Posted onOctober 6, 2023 3:26 pm

Thank you! Posted onOctober 6, 2023 3:24 pm

Thank you for your presentation. May I know the rationale for women's perceiving or is affected more with day time sleepiness. Does that implie that women shouldn't take nap or micro sleep in the day compare to man. thank you again, TarunPosted onOctober 6, 2023 3:23 pm

Hi Dr Salvador, Thank you for your presentation. May I Know how did you control the confounding variables (if were controlled, how did you manage on this population). Tarun Amalnerkar Posted onOctober 6, 2023 3:09 pm

Ih, great work. Congratulations. I would like to know why did you chose pink noise? (e.g., instead of white noise or brown noise). I am Ana a. Gomes, Portugal. Posted onOctober 6, 2023 2:56 pm

Could be the digital CBTi a longitudinal treatment? Katerina Vlami Athens Greece Thank you all very much for your excellent talks!Posted onOctober 6, 2023 2:22 pm

Hello, I cannot hear the livestream and I am chairing the public health session - I sent an email to IT already but have not heard back. email is [email protected] and phone is 513-600-3917 (US)Posted onOctober 6, 2023 1:58 pm

We see more Ciracdian Disturbances in lower incomegroups and external disturbances like light and noise. Is this also researched? What is you idea about that? Winni Hofman, th NetherlandsPosted onOctober 6, 2023 1:53 pm

Good afternoon. Dr Mustafa Emara . Egypt Posted onOctober 6, 2023 1:07 pm

You say that there are little efforts with respect to public health interventions. Maybe not specifically in last year, but wouldn't you say later school times policies and research and development of apps with kind CBT-I interventions for shift workers and the general public would count like this? Ree Meertens, Maastricht UniversityPosted onOctober 6, 2023 1:03 pm

Marijke Gordijn, the Netherlands. Thank you very much Annemarie. With respect to the interventions on a societal level, do you see a stronger role for the ESRS to talk to the EU to stop Daylight Saving Time and to improve sleep in that way. If yes, how could we do that?Posted onOctober 6, 2023 12:58 pm

is there any data about truck drivers other than effect of sleep apnea on motor vehicle accidents? Posted onOctober 6, 2023 12:30 pm

If I understood correctly working only nightshifts does not have negative effects on mental health? (Katarina, Slovenia)Posted onOctober 6, 2023 12:29 pm

Thanks for the grat presentation. What is opinion of wearable consumer products to follow sleep, are their use something to be encouraged, and can we trust them? How well their data synchronizes to clinical level measurements? Sanna Lensu, University of Jyväskylä, FinlandPosted onOctober 6, 2023 12:29 pm

Hello, Deyvis from chile. Thanks for your presentation. ”You mentioned that taking a nap before 1 pm has been shown to be more beneficial. Is there any evidence regarding how long a nap is recommended? Posted onOctober 6, 2023 12:27 pm

Which mechanistic pathways should be investigated in trials with regard to the health effects of improving sleep in those who sleep insufficiently/irregularly? Kind regards André Pacheco, PhD candidate Oslo University Hospital Posted onOctober 6, 2023 12:25 pm

will it make sense to use melatonin in schizophrenia and other mental health conditions as a therapeutic strategy (to advance the sleep phase) ? - William Bara-Jimenez, Bethesda, MDPosted onOctober 6, 2023 12:25 pm

Uthman Albakri, PhD student in the Netherlands. Thank you for your presentation! Regarding the sleep regularity measurement, the Sleep Regularity Index (SRI) doesn't have a specific cut-off point to classify sleep as regular or irregular. Could you please explain how you determined the regularity of sleep in your study?Posted onOctober 6, 2023 12:14 pm

Posted onOctober 6, 2023 12:03 pm

i cant hear anything Posted onOctober 6, 2023 12:01 pm

Could colour of the skin affect hypoxic burden assessment in sleep studies? Posted onOctober 6, 2023 11:43 am

If three nights AHI are derived, will average AHI be the most appropriate outcome to use? Posted onOctober 6, 2023 11:41 am

Christopher McCausland, Ulster University, Northern Ireland. A great set of presentations, thank you. A question for Timo; could you comment on the training time for the deep learning algorithms? Even with access to high performance computing resources the size of PSG training data is typically large. Do you use compact models/limited input data or just accept the extended training time with large input data? Posted onOctober 6, 2023 11:40 am

thank you for your talk. Is there any of those tools available for researchers to use in sleep analysis?Posted onOctober 6, 2023 11:40 am

Good afternoon. Dr Mustafa Emara. Egypt Posted onOctober 6, 2023 11:06 am

Thank you for your sharing knowledge!!Posted onOctober 6, 2023 10:32 am

Thank you for your presentation. What was the the the ratio ale of using electrical stimulation? Kindly put your opinion in impact of exercise. Thank you Tarun Malaysia Posted onOctober 6, 2023 10:24 am

Thank you Ambra Stefani! Since orexin-1 receptors are specific for the brain how side effects outside the brain are explained for orexin-agonists? Posted onOctober 6, 2023 10:17 am

Any suggestions on incidences of narcolepsy or cataplexy I Parkinson's disease. TarunPosted onOctober 6, 2023 9:59 am

Is there really type 2 narcolepsy and how do we explain it?Posted onOctober 6, 2023 9:59 am

Thank you fore your presentation. May we know which will be predominant in narcolepsy phase REM% NREm? And muscle tone. TarunPosted onOctober 6, 2023 9:57 am

Dear Gert Jan, great talk, I fully agree with you that the function of Hypocretin in wake is crucial and we need to understand their exact functions looking at their activity during behaviors, their inputs and outputs. What you believe is the main function of Hypocretin neurons? Pierre-Hervé LuppiPosted onOctober 6, 2023 9:56 am

Inspiring lecture. Is there any data on influence of levels of hypocretine on cataplexy? Why some patients have typical and other atypical cataplexy? How are other wake-promoting neuromediators and systems involved in the disease development? Posted onOctober 6, 2023 9:55 am

Nice speech. But what does evolution theory have to do with science here? the similarities with animals that are found may also indicate the same Creator. I know this is a belief, but evolution is also unproven and therefore also a belief. I'm really a bit disappointed that this is being used here as if it were science. WJ van Veen, NederlandPosted onOctober 6, 2023 9:53 am

I remember Netter illustrations in my student days Dr Ram Vatwani FAAN Consultant Neurologist Bahrain Posted onOctober 6, 2023 9:37 am

thanks for real life cases - from the UK!!Posted onOctober 6, 2023 9:32 am

Thank you for the nice presentation. For Dr Barelli: We have two parkinson patients with this kind of episodes and is surprising than the two patients cry and ask for his mother. Do you have an hipothesis about this relative stereotiped behaviour?Posted onOctober 6, 2023 9:32 am

Monique Vlak, neurologist-somnologist the Nethelands Question for mr Baldelli, Interesting presentation. In the last case, was epilepsy considered given the stereotype presentation in different sleep stages?Posted onOctober 6, 2023 9:29 am

Does acting out the dreams (vocally and physically) have any negative effects? Or can the relative at home (for example) just leave the person by himself because he won't remember it in the morning? Katarina, SloveniaPosted onOctober 6, 2023 9:28 am

To Luca Baldelli - what is the typical EEG in RBD episodes? Is wake-like EEG frequent in RBD episodes?Posted onOctober 6, 2023 9:27 am

very nice talks question for Luca Baldelli very interesting patients, your last case could it be non motor epilepsy? similar eventsPosted onOctober 6, 2023 9:26 am

What is the optimal treatment for chronic insomnia in patients with epilepsy and migraine with aura? Elena Lebedeva, RussiaPosted onOctober 6, 2023 9:26 am

Posted onOctober 6, 2023 9:20 am

Laurent Sheybani (UCL, London, UK and UNIGE, Geneva, Switzerland) - Questions for Luca Baldelli - To my knowledge, the ICSD-3 does not indicate a % of epochs that must show REM without atonia (REMWA) during a PSG for the diagnosis of RBD: does this mean that, for the diagnosis of RBD, we should retain the diagnosis of REMWA with only 1 epoch of 30-s PSG showing REMWA? - In your experience, what is the % of REM-epochs showing REMWA in the early stages of disease?Posted onOctober 6, 2023 9:19 am

Really great cases! (Joana, Portugal)Posted onOctober 6, 2023 9:14 am

Was the focus of origin of epileptic discharges localized topographically with the help of classical EEG in the second case presented by D-r Evelina Pajediene? What was considered as potential etiology for the epilepsy? Is levetiracetam always first choice in the treatment of nocturnal epilepsy having in mind the potential impact of other antiepileptics on sleep structure? - K. Avramov (Bulgaria)Posted onOctober 6, 2023 9:09 am

Question to Dr. Seidel from R. Peraita-Adrados (Spain) Did you perform visual and somatosensory evoked potentials? In addition, optic nerve and retinal nerve fiber scan to your patient?Posted onOctober 6, 2023 9:08 am

To Evalina Pajediene - Thank you for your talk! For your second case - would you prescribe Clonazepam for a co-morbid epilepsy + parasomnia patient?Posted onOctober 6, 2023 9:03 am

Question for prof. Seidel: Did you start any treatment for iron deficiency or EDS? Or "only" treatment of neuromyelitis optica was reccommended? Iva Příhodová Czech RepublicPosted onOctober 6, 2023 8:51 am

Dr Seidel, could you please explain the differentialdiagnosis between MS and NMOSD for the patient?Posted onOctober 6, 2023 8:50 am

To Stefan Seidel - Very interesting case. Is narcolepsy-like syndrome often in such neurologic conditions? How frequent are this type of neurologic conditions in general? Does your patient had any problems with her sight (eyes)? Posted onOctober 6, 2023 8:46 am

Posted onOctober 6, 2023 8:30 am

Good morning, thank you for your presentations. My question to Dieter Kunz: We heard yesterday that insomnia is strongly affecting REMS, if I understood correctly. After your talk, I wonder whether chronobiotic use of melatonin could therefore also improve insomnia. Gilberte Tinguely, SwitzerlandPosted onOctober 6, 2023 7:59 am

(I had some connection issues, I hope this question was not answered before) I have a question for Pierre Champetier. I found your talk very interesting, but I don't understand the reasoning behind the subdivision of slow waves in below than 1 Hz and above or equal to 1Hz. How was it decided? Letizia, BelgiumPosted onOctober 6, 2023 7:56 am

To Dr Shan: Is there any proof of an autoimmune process behind the loss of CRH neurones same way as in case on HCRT-neurones in NT1. Jussi Toppila, FinlandPosted onOctober 6, 2023 7:55 am

Marco, neurology resident from USZ Zürich (Switzerland): Slightly provocative question for Dr. Kunz: would it be hypothetically possible to observe positive effects on the disease progression reating iRBD with benzodiazepines? Posted onOctober 6, 2023 7:53 am

Apart from melatonin, clonazepam is used in RBD. Can it also influence the development of Parkinson disease?Posted onOctober 6, 2023 7:52 am

Do you have a working theory why attention was the only cognitive domain associated with spindle train frequency? (Alin Teodosiu MD, Romania)Posted onOctober 6, 2023 7:50 am

What is the potential role of dynorphin as another neurotransmitter which is altered in narcolepsy type 1? Can you comment on how these changes in neurotransmitters affect the clinical phenotype of narcolepsy? - K. Avramov (Bulgaria)Posted onOctober 6, 2023 7:46 am

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we don't have soundPosted onOctober 6, 2023 7:31 am

Posted onOctober 6, 2023 7:30 am

Good morning, thank you for your presentation. My question is for Dr. Dieter Kunz, Germany. What was the dosis of Matonin used? Would you recommend it in clinical practice in patients with RBD without motor symptoms of PD? Thank you! - Alyne Cordeiro (4th year Neurology Resident - Almada, Portugal)Posted onOctober 6, 2023 7:21 am

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Good morning. Dr Mustafa Emara . Egypt Posted onOctober 6, 2023 7:09 am

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Is it possible to visualize the videos with the communications of the earlier days? For instance, today I could not be here. I would like to visualise it now, if possible. Posted onOctober 5, 2023 8:50 pm

Posted onOctober 5, 2023 8:50 pm

Is it possible to visualize the videos with the communications of the earlier days? For instance, today I could not be here. I would like to visualise it now, if possible. Posted onOctober 5, 2023 8:50 pm

For Dr Lavigne. Thaks for your nice presentation. In order to advance in the knowledge of the interaction between bruxism and AOS, dont you think it would be necessary to use more sophisticated diagnostic tools than EMG recording devices?Posted onOctober 5, 2023 4:51 pm

Hellow my name is Katerina Vlami from Athens Greece I have a question for prof. Lavigne. Can we use sleep bruxism as a biomarker (asking patient for Bruxism) in OSA management since bruxism might be a compensatory effect protecting from sleep apnea? and what about cardiovascular disease can it be used as an index of decreased cardiovascular morbidity since those who have sleep Bruxism share some common genes with those with sleep apnea So those who have simultaneously bruxism and sleep apnea may not be prone to cardiovascular disease ? Thank you very much for your excellent presentation!Posted onOctober 5, 2023 4:51 pm

Does PAP therapy in OSA with coexisting bruxism decrease bruxism? (joana vaz de castro, portugal)Posted onOctober 5, 2023 4:51 pm

To Dr Carra If a patients has sleep bruxism is wearing a dental splint does this cause worsening of silent underlying sleep apnea Posted onOctober 5, 2023 4:29 pm

Loved your talk! wish there were more dentists that would be aware of and/or become more of an airway dentist :)Posted onOctober 5, 2023 4:29 pm

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This is for both dentists: Is there an ideal maxillary dimension when using expansion or dimensions or ratios for diagnosing a small mouth? adults? children? (Joana Vaz de Castro, Lisbon, Portugal)Posted onOctober 5, 2023 4:28 pm

Marian Martinez , Spain: thank you for thenice presentation. Dra Carra, can we think about the possibility of consider that bruxism in AOS children could constitute a different AOS phenotipe?Posted onOctober 5, 2023 4:28 pm

Do we really want to screen patients with minimally symptomatic (likely mild OSA)? They will unlikely tolerate CPAP treatment, but may pose a burden on the waiting list of already busy service. Posted onOctober 5, 2023 4:13 pm

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If any myofunctional therapy was icluded as a combined treament approach to this children? Susana Falardo, PortugalPosted onOctober 5, 2023 4:02 pm

regarding RME and the increase in nasal capacity--isn't this extremely important for longterm health, and the ability for the patient to keep their tongue in a high suction position especially while sleeping---to help prevent various sleep disordered breathing problems later on in life? Have you evaluated the increase in nasal capacity in other studies?Posted onOctober 5, 2023 3:56 pm

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Do short sleepers (not deprived though) suffer from DED? Posted onOctober 5, 2023 3:29 pm

Hello everyone, Deyvis from chile. My question goes to Maria. How many patients you suggest a group for CBTI patients could be constituted in the primary attention setting, in order to have good results? Posted onOctober 5, 2023 3:27 pm

Hello, Jana, thank you for your very interesting talk, do you have any idea about why light have increased alerting effects in older people? in my knowledge, older people their photoreceptors may not function as well as young people.Posted onOctober 5, 2023 3:25 pm

for dry eye: are all dry eye problems related to an underlying sleep problem?Posted onOctober 5, 2023 3:21 pm

Riccardo: did you control for daylight exposure? Thanks, Annelies, Netherlands Posted onOctober 5, 2023 2:46 pm

Laurent Sheybani (UCL, London, UK and UNIGE, Geneva, Switzerland) - Question for Riccardo Cremascoli i-CBT usually works well in first weeks to months but long-term management is more complicated. Do you think that light therapy, on a chronic use, has more chance to maintain a physiological sleep-wake rhythm? Is there a risk of "tolerance"?Posted onOctober 5, 2023 2:45 pm

Laurent Sheybani (UCL, London, UK and UNIGE, Geneva, Switzerland) - Question for Chiara Castiglione Have you checked on a pre/post PSG if the relative content of sleep stages (especially REM sleep) changes? Posted onOctober 5, 2023 2:39 pm

I wonder what you think about the role of metacognitions in insomnia? Both with regard to predisposing and perpetuating factors. Kind regards, André P. Pacheco Oslo university hospital Posted onOctober 5, 2023 2:24 pm

What can we do with the 30% of patients (more or less) that don´t respond to CBT and continue with this hiperarousal state?Posted onOctober 5, 2023 2:24 pm

what % of anxiety patients might actually have an untreated sleep disordered breathing problem (mouth breathing/nasal disuse, etc) USAPosted onOctober 5, 2023 2:22 pm

How could imagery rehearsal therapy for nightmares with targeted memory reactivation used in practice? (Katarina Maučec, Slovenia)Posted onOctober 5, 2023 2:22 pm

To Rick: What kind of treatment for insomnia are you planning to use?Posted onOctober 5, 2023 2:06 pm

Patients with REM-related obstructive sleep apnea also have frequent arousals in REM sleep, any data about their anxiety? (Alakuijala, Finland) Posted onOctober 5, 2023 2:03 pm

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In young mothers with natural sleep deprivation - may it also be "opening door" for other mental problems in the same manner as insomnia?Posted onOctober 5, 2023 12:58 pm

What value could CBT-I have for people who are not clearly insomnia patients, but don't sleep well and want to improve their sleep?Posted onOctober 5, 2023 12:54 pm

What degree of sleep discontinuity might be necessary to result in mental illness? is there evidence of a relationship between mental illness and sleep fragmentation, as defined by EEG ? - William Bara-Jimenez, Bethesda, USAPosted onOctober 5, 2023 12:51 pm

Wonderful talk. Does lemborexant or zolpidem prescribed for insomnia improve or worsen depression Posted onOctober 5, 2023 12:49 pm

Faouzia Kambouche from mostaganem (Algeria)Posted onOctober 5, 2023 12:48 pm

Giulia, University of Augsburg, Germany do you think that the positive effect of insomnia treatment on depression symptoms is mediated by the improvements in sleep or rather an effect of doing CBT and thus an effect of psychotherapy?Posted onOctober 5, 2023 12:46 pm

A traditional point of view in psychiatry is that insomnia is a symptom of depression, rather than a causal risk factor. what do you think here? Masoud Tahmasian, GermanyPosted onOctober 5, 2023 12:45 pm

What were the characteristics of non-respondents to treatment? (Mariana -Belgium)Posted onOctober 5, 2023 12:45 pm

Is online CBT-I also effective to alliviate depression?Posted onOctober 5, 2023 12:44 pm

Can ACT therapy be included as an insomnia treatment?Posted onOctober 5, 2023 12:39 pm

Marian Martinez from Spain to Dr.Riemann: thak you for the presentation!. What is the paper of virtual reality and magnetic or direct electrical stimulation in the treatment of patients with insomnia and concomitant depresion. Is a reality now, is there enought evidence in this sense or is the future?Posted onOctober 5, 2023 12:38 pm

How is it possible to help young mothers in problems with sleep deficiency or insomnia? Klaudia, PolandPosted onOctober 5, 2023 12:29 pm

Do you see much variability in emotional reactivity within patients with insomnia? and if so have you looked at factors association with that - in particular trauma exposure? Kate Porcheret, Norway. Posted onOctober 5, 2023 12:29 pm

Thank you, for your presentation Dr / Ms Chiara May I know your suggestions or comments on impact of depression on HRV, would we be able to find same on HRV as you have found on PSG.Posted onOctober 5, 2023 12:07 pm

Thank you very much for your brilliant presentation, Yon. The arousal identification, of course, is necessary for endotyping, but when you are going with HSAT, the recent reports, we know that arousal burden did not correlate with identifying CVS mortality risk contrary to ventilatory and hypoxic burdens. (Dr KOKA, Sleep Medicine, France)Posted onOctober 5, 2023 11:59 am

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The HSAT-AHI was calculated using TST or total recording time?Posted onOctober 5, 2023 11:53 am

How does your new algorithm compare with WatchPat please?Posted onOctober 5, 2023 11:53 am

Thank you Jon for the great presentation and for discussing the guidelines of good machine learning practice from FDA. Can you elaborate what is the landscape in Europe to have on the market AI-based medical products? Matteo Cesari, Innsbruck, AustriaPosted onOctober 5, 2023 11:52 am

Have you tested the accuracy of Body Sleep detecting arousals in cases of other sleep disturbances e.g. PLMD, narcolepsy, parasomnias, RBD? Jussi Toppila, FinlandPosted onOctober 5, 2023 11:52 am

Is the BodySleep 2.0 more useful in mild-to-moderate OSA patients?Posted onOctober 5, 2023 11:51 am

Christopher McCausland, Ulster University, Northern Ireland. A brilliant presentation, thank you. A question for Jon, what are your thoughts on explainability or interpretability within sleep AI; are the algorithms accepted clinically or still viewed with some suspicion? Posted onOctober 5, 2023 11:49 am

Marian Martínez from Spain. The enormous OSA infradiagnosis leads us to use simple diagnosis methods but the new concept of individual and precision medicine needs more sophisticated algorithms. Scoring arousals is very important. How could we conjugate both concepts?. Maybe AI is the key?Posted onOctober 5, 2023 11:36 am

Thanking Dr Susana for the extraordinary presentation, I wanted to ask what is the way forward? Simplification to increase diagnosis or an extensive characterization of phenotypes with characterization of sleep quality? What do we really need?Posted onOctober 5, 2023 11:27 am

Good afternoon. Dr Mustafa Emara . Egypt Posted onOctober 5, 2023 10:56 am

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Sebastian: In patients with CDKL5 we saw very low REMsleep percentages en mainly central events in NREM sleep. What are your ideas about the differences between the mouse model and humans? Thank yoy. Annelies NetherlandsPosted onOctober 5, 2023 10:28 am

Was orexin A measured in blood or in CSF?Posted onOctober 5, 2023 10:05 am

in Portugal pitolisant is not available yet (probably waiting for infarmed)Posted onOctober 5, 2023 9:25 am

If there's narcolepsy with OSA, excuse mePosted onOctober 5, 2023 9:22 am

Sorry, correction - if there's narcolepsy with OSAPosted onOctober 5, 2023 9:22 am

Sorry, correction - if there's narcolepsy with OSAPosted onOctober 5, 2023 9:22 am

TLMS and SOREMs give important information, its not the same to have two SOREMS vs five SOREMS and a SOREM at the beggining of the nap or at 15 minutes. What do you think about this?Posted onOctober 5, 2023 9:20 am

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maybe in this sense it will be better to use an actigraphy?Posted onOctober 5, 2023 9:13 am

Is CBTi improving CPAP compliance?Posted onOctober 5, 2023 9:12 am

This question is for Hennie Janssen. I was wondering if DORAs will be a therapeutical option in COMISA. What do you think about? Mónica Vicente from SpainPosted onOctober 5, 2023 9:10 am

Madeline Ravesloot, the Netherlands. Fantastic presentation. The evidence is clear. But was curious about the different kinds of insomnia. Any suggestions how to differentiate? I am just a mere ENT surgeonPosted onOctober 5, 2023 9:09 am

do hypnotics have a role in ttt of comisa?Posted onOctober 5, 2023 9:08 am

thank you. great talk really and informativePosted onOctober 5, 2023 9:07 am

To Hennie Janssen - is there higher rate of OSA co-morbidities in COMISA patients? Ischemic heart disease, congenital heart failure, stroke, which are frequent in OSA, are frequent cause of insomnia in OSA and poor compliance. Can you comment on that?Posted onOctober 5, 2023 9:03 am

Thank you. What about other objective measures than PVT e.g. OSLER. PVT has been reported to have some learning curve. Jussi Virkkala, FinlandPosted onOctober 5, 2023 8:51 am

Turning the question the other way around - is there any data on the effect of CPAP on patients with Central disorders with hypersomnolence, for example - narcolespy, that often have residual EDS on pharmacotherapy.Posted onOctober 5, 2023 8:50 am

Are pitolisant and solriamfetol allowed in this indication in all EU? (A. Alakuijala, Finland)Posted onOctober 5, 2023 8:50 am

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As There is no feld for comments where goes: great talk! Congratulations Posted onOctober 5, 2023 8:04 am

What place of new diagnostic "micro" tools You see in clinical practice? For what group of patients? Like screening tool? Dalia Mataciuniene, LithuaniaPosted onOctober 5, 2023 7:59 am

Is multi-night sleep studies important?Posted onOctober 5, 2023 7:59 am

Do you think that osa can be diagnosed without oxymetry recording using new technologies? Posted onOctober 5, 2023 7:56 am

Thank you for a really nice presentation. My question is this: you mentioned that women have a higher risk of cardiovascular morbidity after presenting with ACS. Do you think we should offer women CPAP-treatment at a lower AHI than men? Thank you. - Cresta, Denmark Posted onOctober 5, 2023 7:56 am

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in positionnal OSA is repeatability also consistent? Alexandra Stancu FrancePosted onOctober 5, 2023 7:55 am

How is it possible that 8/hr is enough for PG, while with PGs you always score more hypopneas due to the lack of sleep stages (you also count wakefulness)? Williejanne van Veen, Nederland Posted onOctober 5, 2023 7:54 am

what were the causes of the increase in hospitalizations in patients with OSAS?Posted onOctober 5, 2023 7:53 am

Thank you very much Johan for this nice presentation. Do you think AI that is performing and scoring sleep study, and phenotyping the patient will take the place of sleep specialists in the future? Özen BasogluPosted onOctober 5, 2023 7:53 am

What is the actual role of pharmacological therapy in clinical practice? Are there drugs approved in Europe? where are we?Posted onOctober 5, 2023 7:46 am

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Meanwhile, what do we do for our patients with mild or moderate OSAS and heart failure, for example? Should we always offer CPAP treatment? At least one trial?Posted onOctober 5, 2023 7:28 am

Sorry, but you haven't asked my question. I wanted to hear a comment on the potential co-morbidity in some patients of OSA and CSA? How this changes therapy efficacy and prognosis?Posted onOctober 5, 2023 7:28 am

Thank you very much Silke for this excellent talk. What is your treatment choice for the patients with mild, non-sleepy OSA and having CVD. Thank you... Özen BasogluPosted onOctober 5, 2023 7:28 am

should we treat patients without cardio vascular problems and without daytime sleepiness at all? Posted onOctober 5, 2023 7:26 am

A recent ATS position paper suggested 2-3 hours of CPAP compliance may be sufficient. Any comments?Posted onOctober 5, 2023 7:26 am

Sleep apnea is a progresive disease, worsening throught the years. When we have to prevent to get cardivascular effect.Posted onOctober 5, 2023 7:26 am

In the O´Donnell study the sleepy pts were included?Posted onOctober 5, 2023 7:23 am

Great talk! Can you comment on co-morbidity between Obstructive and Central Sleep Apnea? How it affects therapy-efficacy and prognosisPosted onOctober 5, 2023 7:23 am

Good morning. Dr Mustafa Emara. Egypt.Posted onOctober 5, 2023 7:20 am

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************* Day 2 *****************Posted onOctober 5, 2023 6:50 am

Day 2____________________________________________________________________________________________Posted onOctober 5, 2023 6:47 am

test222Posted onOctober 4, 2023 5:04 pm

test111Posted onOctober 4, 2023 5:03 pm

That was fun! Thanks for your effortsPosted onOctober 4, 2023 4:44 pm

This excellent Kahoot and high disagreement shows us how much standardization is still needed in my opinion. I also always wonder about the validity of our likely arbitrary rules for switching between sleep stages every 30 seconds and what determines how that is done when I see the complexity of the rules (Erna Sif Arnardottir, Iceland)Posted onOctober 4, 2023 4:15 pm

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Not able to Connect the gamePosted onOctober 4, 2023 3:59 pm

We are not seeing the slides in presentation mode Posted onOctober 4, 2023 3:42 pm

Not sure if the presenter knows that the presenter view is showing and not the actual showint PP view Posted onOctober 4, 2023 3:38 pm

Clinically, could noradrenergic blockade be a possible therapeutic strategy for the management oof sleep fragmentation? - William Bara-Jimenez, Bethesda (USA)Posted onOctober 4, 2023 3:31 pm

Clinically, could noradrenergic blockade be a possible therapeutic strategy for the management oof sleep fragmentation? - William Bara-Jimenez, Bethesda (USA)Posted onOctober 4, 2023 3:31 pm

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BDNF is also neural activity dependent so do you think it's produced by neurons and then transported to astrocytesPosted onOctober 4, 2023 3:29 pm

I asked this question but forgot to mention my name. Giorgio Corsi, Lausanne, SwitzerlandPosted onOctober 4, 2023 3:28 pm

For Dr Meijer: Does layer 6b silencing affect sleep wake parameters compared to wild-type Jussi Toppila, FinlandPosted onOctober 4, 2023 3:25 pm

Armelle, maybe I missed something. How can you be sure that the effects of BDNF on sleep are mediated by astrocytes? Thank youPosted onOctober 4, 2023 3:20 pm

Where can I read the full paper? - Tomás, PortugalPosted onOctober 4, 2023 3:12 pm

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What about oxygen level? Posted onOctober 4, 2023 2:21 pm

Why in almost all species that sleep has been studied, eye movements are an aspect of sleep? Maybe LiorPosted onOctober 4, 2023 2:18 pm

What about MEAs on brain slices for local sleep?Posted onOctober 4, 2023 2:15 pm

technical question to Charlotte from Sebastien ARTHAUD (from LYON, France): how do you manage wearing the wireless implant on the pups when they are with their mother in their cage ? How is energy supplied the implant ? Thank youPosted onOctober 4, 2023 2:11 pm

Question for Mojtaba: Can sleep during development and ageing be studied in a dish? E.g. are slow oscillations stronger in cell cultures created from young animals and are they disrupted in cell cultures of aged animals or animal models of neurodegenerative diseases? Posted onOctober 4, 2023 2:10 pm

Is it possible to reveal abnormalities on functional MRI in patients with narcolepsy? Elena Lebedeva, RussiaPosted onOctober 4, 2023 2:10 pm

What kind of wearables have been used in the last part?Posted onOctober 4, 2023 2:04 pm

Laurent Sheybani (London, UK and Geneva, Switzerland) - Question for Mojtaba Bandarabadi In these cultured cells, how reproducible was the direction of propagation? If there was a consistent direction, what do you think would be the underlying mechanism driving this particular direction?Posted onOctober 4, 2023 2:03 pm

From Pierre-Hervé Luppi (you can guess with the use of PS!) Posted onOctober 4, 2023 2:00 pm

Question for Charlotte, in pups there is mainly paradoxical sleep, I wonder what type of activity you get? Do you monitor muscle atonia?Posted onOctober 4, 2023 1:59 pm

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Christian Jimenez PerúPosted onOctober 4, 2023 1:21 pm

Could depression treatment, that is antidepressants, improve the glymphatic system? Thank you. Posted onOctober 4, 2023 1:19 pm

Any possible (more specific) role of the autonomic nervous system in modulating the GS, other than though cardiovascular effects? - William Bara-Jimenez, USPosted onOctober 4, 2023 1:19 pm

Is high blood preassure associated with this enlargement of perivascular spaces?Posted onOctober 4, 2023 1:16 pm

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Is there any activity of the GS during wakefulness? How about during REM sleep?Posted onOctober 4, 2023 1:15 pm

How this works during hibernation?Posted onOctober 4, 2023 1:15 pm

There is synaptic downscaling during SWS. Is it possible that this downscaling makes glymphatic flow possible during SWS Jussi Toppila, FinlandPosted onOctober 4, 2023 1:13 pm

Great lecture! Any thoughts on the potential role of glymphatic system and mental illness? - William Bara-JImenez, USAPosted onOctober 4, 2023 1:12 pm

Is valid to study de Glymphatic System in Humans by MRI despite being awake? should be using anesthesia? Is valid the results in awakes patients? Posted onOctober 4, 2023 1:12 pm

Short follow-up: if i recall correctly, during fixation processes the PVS is (partly) collapsed, which could explain that tracer entrance into the brain parenchyma could happen post-mortem, right? Posted onOctober 4, 2023 1:11 pm

Since anesthesia does the same, is this sleep function or just a correlate of reduced activity?Posted onOctober 4, 2023 1:09 pm

Atrial fibrillation is characterized by irregular heart beat: How might this influence the flow in the perivascular space, and glymphatic clearance of metabolites? And what about coronary heart disease - or small vessel atherosclerosis in general - would this decrease or increase pulsatility of the perforants from the pial vessel, and how would this reasonably affect glympatic function? Kind regards, Andre Pacheco, Oslo University Hospital Posted onOctober 4, 2023 1:07 pm

In the macroscopic imaging experiment, what was actually the evidence or observation that the tracer passes through the brain parenchyma, and not just remains in the PVS?Posted onOctober 4, 2023 1:06 pm

Greg Elder (UK): Thank you for a very interesting talk. Posted onOctober 4, 2023 1:06 pm

Has glymphatic efflux been measured in mice? (Lukas Krone, Switzerland) Posted onOctober 4, 2023 1:05 pm

Thank you for your wonderful lecture! Is it possible that increased intracranial pressure can influent on glymphatic system? Elena Lebedeva, Russia Posted onOctober 4, 2023 1:05 pm

Is there a difference in glymphatic system activity between REM and NREM sleep? Is the glymphatic system more active at the beginning of the sleep bout, or towards the end? (Elena Krugliakova, the Netherlands)Posted onOctober 4, 2023 1:05 pm

What is happening to the glymphatic system during REM sleep? Posted onOctober 4, 2023 1:05 pm

Pierre-Hugues Prouvot (Switzerland): Thank you I learned a lot with that talk. Do you think REM sleep is specifically important in this flushing mechanism owing to the increase in bloodflow and vasodilation during that period? So REM sleep perturbation during AD or PD could worsen the situation even further. Posted onOctober 4, 2023 1:04 pm

What would you consider the electrophysiological correlate to be in relation to cerebrospinal fluid oscillations associated with glymphatic system involvement? - K. Avramov, Bulgaria Posted onOctober 4, 2023 1:03 pm

Where does the cerebral lymph drain in humans? Harald Hrubos-Strøm, Norway Posted onOctober 4, 2023 1:01 pm

Is the diet affecting the glial amount of acylcarnitines or lipid droplets, might this be relevant in humans especially? Sanna Lensu/FinlandPosted onOctober 4, 2023 12:32 pm

Laurent Sheybani (London, UK and Geneva, Switzerland) - Have you tested whether there is an activity-dependent accumulation of lipid droplets in glia (i.e., the accumulation is particularly high in regions that were particularly active during wakefulness) ? [sorry for the repeat, I don't know whether my question was transferred]Posted onOctober 4, 2023 12:29 pm

Do insomniac mutant flies have more lipid droplets? Can an increase in sleep reduce lipid droplets?Posted onOctober 4, 2023 12:25 pm

What does she think about the role of microbiome to module the gene (APOE-4), by attempting the levels of biochemical stimulation to switch on or off these genes. Posted onOctober 4, 2023 12:25 pm

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Thank you for your very good lecture! What do you think about of the role of lipid homeostasis in the development of hypersomnolence? Elena Lebedeva, RussiaPosted onOctober 4, 2023 12:24 pm

Did you measure the lifespan of some of your mutants? Does the chronic sleep loss affect life expectancy of fruit flies? Lukas Krone (Switzerland) Posted onOctober 4, 2023 12:24 pm

Thanks for the fascinating talk ? Do you think that NREM and REM sleep (or their equivalent in flies) may have different roles in metabolic homeostasis ?Posted onOctober 4, 2023 12:23 pm

How is acyl carnitine linked to neuronal activity? is accumulation different depending on neuronal subtype activity? Posted onOctober 4, 2023 12:22 pm

Is there any evidence that the brain processes long chain fatty acids (neurons vs glia)?Posted onOctober 4, 2023 12:22 pm

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Laurent Sheybani (London, UK and Geneva, Switzerland) - Have you tested if there is an activity-dependent accumulation of lipid droplets (i.e., accumulation of lipid droplets is higher in regions that were more activated than others during wakefulness) ?Posted onOctober 4, 2023 12:20 pm

Good afternoon. Dr Mustafa Emara .Egypt.Posted onOctober 4, 2023 11:58 am

Dr Joseph Yohanna, Nigeria but currently in UK on clinical attachment Posted onOctober 4, 2023 11:33 am

Just builds sleep laboratory in my hospital, Federal Teaching Hospital Katsina, Nigeria West Africa. What do you think is the basics we need to have a good and effective sleep clinic and research centre Posted onOctober 4, 2023 11:31 am

HiPosted onOctober 4, 2023 11:11 am

testing 1234Posted onOctober 4, 2023 11:04 am

Were the sessional patterns of sleep (e.g., low SWS in summer) associated with depression and cognitive performance of your subjects? Masoud Tahmasian, Germany Posted onOctober 4, 2023 10:32 am

A question for Christine - how do you think we can recocile your non-sig. data from humans with the data from mice in Mouland et al 2019 study? Is is due to differences between nocturnal and diurnal species?Posted onOctober 4, 2023 10:31 am

Christopher McCausland, Ulster University, Northern Ireland. Great presentations thank you. A question for Christian, has your work investigated any other arrhythmia irregularities such as Premature Ventricular Contractions within sleep?Posted onOctober 4, 2023 10:31 am

Any comments on HRV measurement / hrv measurement devices? Posted onOctober 4, 2023 10:30 am

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Is it possible that green light can have positive influence for sleep and increase of melatonin production? Elena Lebedeva, RussiaPosted onOctober 4, 2023 10:29 am

Hi Ms. Valentina Elce Thank you for your presentation. may we know any input on any suggestions on scales / or objective methods used to assess the dream ? Posted onOctober 4, 2023 10:29 am

Hi, Thank you for your reply and valuable input Mr Mikutta. Posted onOctober 4, 2023 10:26 am

Giulia Zerbini, University of Augsburg (Germany) Question for Valentina Elce: Many thanks for the interesting talk. You mentioned that sleep onset and offset are predictors of dream recall frequency. Could you tell us more about this relationship? Are for example later or earlier sleep times related to a higher frequency of dream recall?Posted onOctober 4, 2023 10:14 am

Is any specific centre for dream - M.A.Aleem Neurologist Trichy Tamilnadu India Posted onOctober 4, 2023 10:11 am

to Florentine Klepel What is your opinion : Does it mean that more frequent spindles are the functional marker of the locus coeruleus higher activity? Jasna Saponjic, SerbiaPosted onOctober 4, 2023 9:59 am

Laurent Sheybani (London, UK and Geneva, Switzerland) - Have you find some sort of "entrainment"? That is, increased DE across the 14 days? Or a change in dream content across the experimental timeline? Posted onOctober 4, 2023 9:56 am

Laurent Sheybani (London, UK and Geneva, Switzerland) - The LC seemed to be asymmetrically activated or did I misinterpreted the figure? Thank for the presentation!Posted onOctober 4, 2023 9:49 am

Thank you for your lovely presentations. How did you control the impact of hr variability in experimental studies. How much time you advise for acclimatization / sleep with HR Variability instrument in rat and for human experiments. will appreciate if you can comment on HR V measurement (at affordable price). Thank you, TarunPosted onOctober 4, 2023 9:45 am

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To Malcom: Do you think that our difficulty in communicating to our policy makers (convincingly) relates to the relatively low proof level that DST is bad for health?Posted onOctober 4, 2023 9:23 am

Missed the beginning. Can we access video lectures after congress? Jussi Virkkala, FinlandPosted onOctober 4, 2023 9:22 am

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Thank you for your presentation! Regarding the digital sleep-wake intervention, how did you measure the sleep quality of shift workers? And what kind of shift do the workers have?Posted onOctober 4, 2023 8:43 am

Wow Posted onOctober 4, 2023 8:33 am

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Isabelle Lambert (France) : how do you precisely determine the up and down states in intracranial recordings ?Posted onOctober 4, 2023 8:06 am

Jimmy (Montreal, Canada): Have you looked at criticality measures to explore a potential link with the disruption of SW-spindles-ripples coupling?Posted onOctober 4, 2023 8:02 am

Very interesting talk. I am also interested in sleep and memory consolidation and the use of closed-loop TMR in older adults and people with Parkinson's disease. How can we know for sure that with the auditory stimuli we are actually reactivating specific memories and not increasing the coupling in a non-specific manner? Letizia Micca, KU Leuven, BelgiumPosted onOctober 4, 2023 8:01 am

Thank you for presenting your amazing work. Question on the iEEG coupling study: The fact that these were epileptic patients, how did that impact results? E.g. the non-coupling nights, were there more nocturnal seizures that might impact memory consolidation as well? Denise Bijlenga, The Netherlands. Posted onOctober 4, 2023 7:58 am

Do we have any knowledge if aromatherapy can influence consolidation? Posted onOctober 4, 2023 7:57 am

Angela Gomez. Netherlands. Do you have data on changes in sleep spindles (density, relative frequency) under different light exposures?Posted onOctober 4, 2023 7:33 am

Superb tqlk Christian thank you - could the effects of daytime light on nocturnal sleep go through a change in amplitude on the circadian oscillation rather than on H process per se ?Posted onOctober 4, 2023 7:32 am

What do you think about light therapy and its use in treating e.g. depression or seasonal mood disorders? (Patrycja, Poland) Posted onOctober 4, 2023 7:30 am

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Dear Professor Cajochen, Thank you for interesting lecture! Could you please tell, is green light positive for sleep and increase of melatonin level? It was shown recently for headache treatement (Buse at al, 2023). Elena Lebedeva, Russia Posted onOctober 4, 2023 7:28 am

Could the increase in delta activity during sleep after exposure to blue light be a compensatory reaction rather than direct consequence? In other word isn't it too brisk to say that blue light infamy is to be discarded, based on the present unclear cause-and-effect relationship?Posted onOctober 4, 2023 7:24 am

Peter Meerlo, Netherlands: You showed increased in EEG deltapower during sleep with increased light intensity during the day, perhaps suggesting that light affects the build-up of sleep need/pressure. Where the increases in deltapower global or localised to certain parts of the cortex (e.g., visual cortex)? Posted onOctober 4, 2023 7:21 am

Zarifa Jalilova Baku Azerbaycan. Thank you!!))👍🤝Posted onOctober 4, 2023 7:11 am

fix it sorryPosted onOctober 4, 2023 7:10 am

audio is not working Posted onOctober 4, 2023 7:10 am

Good morning.Dr Mustafa Emara.EgyptPosted onOctober 4, 2023 7:09 am

I cannot hear you Gilberte Tinguely, SwitzerlandPosted onOctober 4, 2023 7:01 am

testing 123Posted onOctober 3, 2023 10:14 am

Test 123Posted onOctober 2, 2023 8:53 am